EP1013 Inhibitor

Name: EP1013 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753101
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753101

EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EP1013, Inhibitor

Full Product Name

EP1013

Product Gene Name

EP1013, inhibitor

Product Synonym Names

F1013

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

382.38

Solubility

DMSO: 60mg/mL (156.91mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H23FN2O6

SMILES

O=C(O)C[C@H](NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)C(CF)=O

CAS Number

223568-55-6

Target & IC50

Caspase

In Vitro

EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function.EP1013 (1, 3, 10mg/kg) significantly improves marginal islet mass function. Two animals in the 10mg/kg EP1013 treatment, group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3mg/kg EP1013, 1mg/kg EP1013, or 10mg/kg zVAD groups.

Product Categories/Family for EP1013, inhibitor

Apoptosis; Caspase; Proteases/Proteasome

Product References and Citations for EP1013, inhibitor

Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.
Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.

Other Notes

Small volumes of EP1013, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EP1013 purchase

MBS5753101 is an inhibitor targeting EP1013.