DXD Inhibitor

Name: DXD Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753117
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753117

Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31uM). It is used as a conjugated drug of HER2-targeting ADC. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dxd, Inhibitor

Full Product Name

Dxd

Product Gene Name

Dxd, inhibitor

Product Synonym Names

Exatecan derivative for ADC

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

493.48

Solubility

DMSO: 50mg/mL (101.32mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H24FN3O6

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC(CO)=O)C(C)=C(F)C=C6N=C4C3=C2)=O

CAS Number

1599440-33-1

Target & IC50

Topoisomerase I: ic50 0.31uM
Camptothecins

In Vitro

DS-8201a (Dxd is the payload, 10mg/kg, i.v.) displays potent antitumor activity in HER2-positive models with KPL4, JIMT-1, and Capan-1. In HER2 low-expressing ST565 and ST313 models has HER2 IHC 1+/FISH-negative expression.

Product Categories/Family for Dxd, inhibitor

DNA Damage/DNA Repair; Topoisomerase

Product References and Citations for Dxd, inhibitor

Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DMClin Cancer Res. 2016 Oct 15;22(20):5097-5108.
Ogitani Y, et al. DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1. Clin Cancer Res. 2016 Oct 15;22(20):5097-5108.

Other Notes

Small volumes of Dxd, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dxd purchase

MBS5753117 is an inhibitor targeting Dxd.