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FGTI-2734 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753124

FGTI-2734 can prevent membrane localization of KRAS, hence solving KRAS resistance problem and thwarting mutant KRAS patient-derived pancreatic tumors. FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FGTI-2734, Inhibitor
Full Product Name
FGTI-2734
Product Gene Name
FGTI-2734, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
510.63
Solubility
DMSO: 50mg/mL (97.92mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H31FN6O2S
SMILES
O=S(C1=NC=CC=C1)(N(CCN(C2=CC=C(C#N)C=C2F)CC3=CN=CN3C)CC4CCCCC4)=O
CAS Number
1247018-19-4
Target & IC50
FT: ic50 250nM
GGT-1: ic50 520nM

Structure of FGTI-2734, inhibitor

FGTI-2734 Inhibitor – Cat# MBS5753124

Product References and Citations for FGTI-2734, inhibitor

Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21.
Kazi A, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clin Cancer Res. 2019 Jun 21.

Other Notes

Small volumes of FGTI-2734, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGTI-2734 purchase

MBS5753124 is an inhibitor targeting FGTI-2734.
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