(S)-Oxiracetam Inhibitor

MBS5753129 is an inhibitor targeting (S)-Oxiracetam. (S)-Oxiracetam is a positive allosteric the AMPA receptorsmodulator.

Li W, Liu H, Jiang H, Wang C, Guo Y, Sun Y, Zhao X, Xiong X, Zhang X, Zhang K, Nie Z, Pu X. (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Sci Rep. 2017 Aug 30;7(1):10052. doi: 10.1038/s41598-017-10283-4. PubMed PMID: 28855592; PubMed Central PMCID: PMC5577264.
Huang L, Shang E, Fan W, Li X, Li B, He S, Fu Y, Zhang Y, Li Y, Fang W. S-oxiracetam protect against ischemic stroke via alleviating blood brain barrier dysfunction in rats. Eur J Pharm Sci. 2017 Nov 15;109:40-47. doi: 10.1016/j.ejps.2017.07.029. Epub 2017 Jul 29. PubMed PMID: 28760594.
Wang W, Ji H, Li T, Jia Y, Xie H. Pharmacokinetic comparisons of S-oxiracetam and R-oxiracetam in beagle dogs. Acta Pharm. 2016 Jun 1;66(2):279-87. doi: 10.1515/acph-2016-0013. PubMed PMID: 27279070.
Zhang Q, Yang W, Zhang Q, Yang Y, Li J, Lu Y, Zheng Y, He J, Zhao D, Chen X. Enantioselective HPLC determination of oxiracetam enantiomers and application to a pharmacokinetic study in beagle dogs. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jul 1;993-994:9-13. doi: 10.1016/j.jchromb.2015.04.033. Epub 2015 Apr 30. PubMed PMID: 25978861.

Small volumes of (S)-Oxiracetam, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.