FMF-04-159-2 Inhibitor

Name: FMF-04-159-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753137
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753137

FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6nM and 256nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FMF-04-159-2, Inhibitor

Full Product Name

FMF-04-159-2

Product Gene Name

FMF-04-159-2, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

683.01

Solubility

DMSO: 250mg/mL (366.03mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H30Cl3N7O5S

SMILES

O=C(C1=NNC=C1NC(C2=C(Cl)C=C(Cl)C=C2Cl)=O)NC3CCN(S(=O)(C4=CC=CC(NC(/C=C/CN(C)C)=O)=C4)=O)CC3

CAS Number

2364489-81-4

Target & IC50

CDK14/Cyclin Y: ic50 39.6nM (in NanoBRET assay)
CDK2: ic50 256nM (in NanoBRET assay)

Product Categories/Family for FMF-04-159-2, inhibitor

Cell Cycle/Checkpoint; CDK

Product References and Citations for FMF-04-159-2, inhibitor

Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 1pii: S2451-9456(19)30070-4.
Ferguson FM, et al. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.

Other Notes

Small volumes of FMF-04-159-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FMF-04-159-2 purchase

MBS5753137 is an inhibitor targeting FMF-04-159-2.