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GKI-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753190

GKI-1 robustly inhibits ROCK1 with an IC50 of 11uM, but only weakly affected PKA. GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5uM against hGWLFL and hGWL-KinDom, respectively. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GKI-1, Inhibitor
Full Product Name
GKI-1
Product Gene Name
GKI-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
269.73
Solubility
DMSO: 200mg/mL (741.48mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H12ClN3
SMILES
ClC(C=C1)=CC=C1NC2=CC(C3=CNN=C3)=CC=C2
Target & IC50
hGWLFL: ic50 4.9uM
hGWL-KinDom: ic50 4.9uM

Structure of GKI-1, inhibitor

GKI-1 Inhibitor – Cat# MBS5753190

Product References and Citations for GKI-1, inhibitor

Ocasio CA, et al. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget. 2016 Nov 1;7(44):71182-71197.
Ocasio CA, et al. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget. 2016 Nov 1;7(44):71182-71197.

Other Notes

Small volumes of GKI-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GKI-1 purchase

MBS5753190 is an inhibitor targeting GKI-1.
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