GNF4877 Inhibitor

Name: GNF4877 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753214
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753214

GNF4877 is a potent DYRK1A and GSK3beta inhibitor (IC50s: 6nM and 16nM). It leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased beta-cell proliferation cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNF4877, Inhibitor

Full Product Name

GNF4877

Product Gene Name

GNF4877, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

494.52

Solubility

DMSO: 4.17mg/mL (8.43mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H27FN6O4

SMILES

O=C([C@H]1CN(C2=C(NC(C3=NC(C4=CC(OC(C)C)=CC=C4F)=CN=C3N)=O)C=NC=C2)CCC1)O

CAS Number

2041073-22-5

Target & IC50

GSK3beta: ic50 16nM
DYRK1A: ic50 6nM

Product Categories/Family for GNF4877, inhibitor

Cell Cycle/Checkpoint; DYRK

Product References and Citations for GNF4877, inhibitor

Shen W, et al. Inhibition of DYRK1A and GSK3beta induces human beta-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.
Shen W, et al. Inhibition of DYRK1A and GSK3beta induces human beta-cell proliferation. Nat Commun. 2015 Oct 26;6:8372.

Other Notes

Small volumes of GNF4877, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNF4877 purchase

MBS5753214 is an inhibitor targeting GNF4877.