• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GSK2850163 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753246

GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1alpha) which can inhibit RNase activity and IRE1alpha kinase activity (IC50s: 200 and 20nM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GSK2850163, Inhibitor
Full Product Name
GSK2850163
Product Gene Name
GSK2850163, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
446.41
Solubility
DMSO: 67.5mg/mL (151.21mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C24H29Cl2N3O
SMILES
O=C(N(CCC1)C[C@]21CCN(CC3=CC=C(Cl)C(Cl)=C3)C2)NCC4=CC=C(C)C=C4
CAS Number
2121989-91-9
Target & IC50
IRE1alpha kinase activity: ic50 20nM
IRE1alpha RNase activity: ic50 200nM

Structure of GSK2850163, inhibitor

GSK2850163 Inhibitor – Cat# MBS5753246

Product References and Citations for GSK2850163, inhibitor

Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1alpha Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.
Nestor O. Concha, et al. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1alpha Endoribonuclease Activity. Molecular Pharmacology December 2015, 88 (6) 1011-1023.

Other Notes

Small volumes of GSK2850163, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK2850163 purchase

MBS5753246 is an inhibitor targeting GSK2850163.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000