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GSK4027 Inhibitor – GSK 4027

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753250

GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4+/-0.11 for PCAF. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GSK 4027 (GSK4027), Inhibitor
Full Product Name
GSK 4027
Product Gene Name
GSK4027, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
377.28
Solubility
DMSO: 50mg/mL (132.53mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H21BrN4O
SMILES
BrC1=C(N[C@@H]2C[C@H](C3=CC=CC=C3)CN(C)C2)C=NN(C)C1=O
CAS Number
2079896-25-4
Target & IC50
PCAF: ic50 7.4+/-0.11 (pic50)

Structure of GSK4027, inhibitor

GSK4027 Inhibitor – Cat# MBS5753250

Product References and Citations for GSK4027, inhibitor

Humphreys PG, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60(2):695-709.
Humphreys PG, et al. Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe. J Med Chem. 2017 Jan 26;60(2):695-709.

Other Notes

Small volumes of GSK4027, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK4027 purchase

MBS5753250 is an inhibitor targeting GSK4027. Also known as GSK 4027.
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