GSTO1-IN-1 Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

311.18

DMSO: 300mg/mL (964.07mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

C10H12Cl2N2O3S

O=C(NC1=CC=C(Cl)C(S(=O)(N(C)C)=O)=C1)CCl

568544-03-6

GSTO1: ic50 31nM

To test whether GSTO1-IN-1 had in vivo efficacy, its effects are evaluated in a human colon cancer cell line xenograft model. GSTO1-IN-1 (20-45mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment,is generally well tolerated by mice up to 45mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study.