HA155 Inhibitor

MBS5753273 is an inhibitor targeting HA155. HA-155 is a selective and potent autotaxin (ATX) inhibitor (IC50: 5.7nM).

Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603.
Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603.
Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54(13):4619-26.
Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54(13):4619-26.
Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286(40):34654-63.
Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286(40):34654-63.

Small volumes of HA155, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.