HDACs/mTOR1 Inhibitor – Hdacs/Mtor 1

Name: HDACs/mTOR1 Inhibitor; Hdacs/Mtor 1; MyBioSource
Brand: MyBioSource
SKU: MBS5753274
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753274

HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19nM, 1.8nM, 1.2nM, and >500nM for HDAC1, HDAC6, mTOR and PI3Kalpha). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HDACs/mTOR 1 (HDACs/mTOR1), Inhibitor

Full Product Name

HDACs/mTOR Inhibitor 1

Product Gene Name

HDACs/mTOR1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

566.65

Solubility

DMSO: 32.5mg/mL (57.35mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H38N8O5

SMILES

O=C(NO)CCCCCCN1C2=NC(C3=CC=C(NC(N4C[C@@H](C)OCC4)=O)C=C3)=NC(N5CCOCC5)=C2C=N1

CAS Number

2271413-06-8

Target & IC50

HDAC1: ic50 0.19nM
HDAC6: ic50 1.8nM
mTOR: ic50 1.2nM

In Vitro

HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in the G0/G1 phase and induces tumor cell apoptosis with low toxicity in vivo.

Product Categories/Family for HDACs/mTOR1, inhibitor

Chromatin/Epigenetic; HDAC; DNA Damage/DNA Repair

Product References and Citations for HDACs/mTOR1, inhibitor

Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.
Chen Y, et al. Discovery of a Novel Dual Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin (mTOR) Target Inhibitor as a Promising Strategy for Cancer Therapy. J Med Chem. 2019 Jan 10.

Other Notes

Small volumes of HDACs/mTOR1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HDACs/mTOR1 purchase

MBS5753274 is an inhibitor targeting HDACs/mTOR1. Also known as HDACs/mTOR Inhibitor 1.