I2906 Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

443.58

<1mg/ml refers to the product slightly soluble or insoluble

C25H37N3O4

O=C1C(C(NNC(CCCCCCCCCCCC)=O)=O)=C(O)C2=CC=CC=C2N1CC

331963-29-2

Others

In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p <0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p <0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, the survival rate was increased by I2906 treatment, For multidrug-resistant strain infection, bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment,in comparison with data from untreated controls (p <0.05).