IAXO-102 Inhibitor

Name: IAXO-102 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753299
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753299

IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-kappaB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IAXO-102, Inhibitor

Full Product Name

IAXO-102

Product Gene Name

IAXO-102, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

585.94

Solubility

Ethanol: 50mg/mL (85.33mM) Need ultrasonic
DMSO: <1mg/mL (insoluble or slightly soluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C35H71NO5

SMILES

CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@@H](CN)O[C@@H]1OC)O)OCCCCCCCCCCCCCC

CAS Number

1115270-63-7

Target & IC50

TLR4

In Vitro

IAXO-102 (3mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice.

Product Categories/Family for IAXO-102, inhibitor

Immunology/Inflammation; TLR

Product References and Citations for IAXO-102, inhibitor

Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.
Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70.

Other Notes

Small volumes of IAXO-102, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IAXO-102 purchase

MBS5753299 is an inhibitor targeting IAXO-102.