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INT-777 Inhibitor – R-Enantiomer

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753330

INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 uM for TGR5. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
INT-777 R-enantiomer, Inhibitor
Full Product Name
INT-777 R-enantiomer
Product Gene Name
INT-777, inhibitor
Product Synonym Names
S-EMCA R enantiomer
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
450.65
Solubility
DMSO: 100mg/mL (221.90mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H46O5
SMILES
O[C@@H]1CC[C@@]2(C)[C@@]([C@@H](CC)[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@H](C)C[C@@H](C)C(O)=O)([H])C1
CAS Number
1198786-98-9
Target & IC50
Others
In Vitro
INT-777 is more choleretic than CA, but less than INT-777.

Structure of INT-777, inhibitor

INT-777 Inhibitor – Cat# MBS5753330

Product References and Citations for INT-777, inhibitor

Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-6

Other Notes

Small volumes of INT-777, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INT-777 purchase

MBS5753330 is an inhibitor targeting INT-777. Also known as INT-777 R-enantiomer.
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