Jaspamycin Inhibitor

Name: Jaspamycin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753346
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753346

Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIalpha. Anti-parasite activity. Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5nM and Kd of 8nM in Trypanosoma brucei. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Jaspamycin, Inhibitor

Full Product Name

Jaspamycin

Product Synonym Names

7-CN-7-C-Ino

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

292.25

Solubility

DMSO: 41.67mg/mL (142.58mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C12H12N4O5

SMILES

O=C1C2=C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C2C#N)N=CN1

CAS Number

22242-96-2

Target & IC50

Trypanosoma brucei PKA holoenzyme: ic50 8nM (Kd)
Trypanosoma brucei PKAR: ic50 6.5nM (EC50)

Product Categories/Family for Jaspamycin, inhibitor

Angiogenesis; JAK; Others

Product References and Citations for Jaspamycin, inhibitor

Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.

Other Notes

Small volumes of Jaspamycin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Jaspamycin purchase

MBS5753346 is an inhibitor targeting Jaspamycin.