KDOAM-25 Inhibitor – Citrate

Name: KDOAM-25 Inhibitor; Citrate; MyBioSource
Brand: MyBioSource
SKU: MBS5753364
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753364

KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells. KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71nM,… More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

KDOAM-25 citrate, Inhibitor

Full Product Name

KDOAM-25 citrate

Product Gene Name

KDOAM-25, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

499.51

Solubility

DMSO: 200mg/mL (400.39mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H33N5O9

SMILES

NC(C1=CC=NC(CNCC(N(CC)CCN(C)C)=O)=C1)=O.OC(CC(C(O)=O)(O)CC(O)=O)=O

Target & IC50

KDM5A: ic50 71nM
KDM5B: ic50 19nM
KDM5C: ic50 69nM
KDM5D: ic50 69nM

Product Categories/Family for KDOAM-25, inhibitor

Chromatin/Epigenetic

Product References and Citations for KDOAM-25, inhibitor

Tumber A, et al. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol. 2017 Mar 16;24(3):371-380.

Other Notes

Small volumes of KDOAM-25, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDOAM-25 purchase

MBS5753364 is an inhibitor targeting KDOAM-25. Also known as KDOAM-25 citrate.