KEAP1-NRF2-IN-1 Inhibitor

Name: KEAP1-NRF2-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753365
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753365

Keap1-Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1-Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Keap1-Nrf2-IN-1, Inhibitor

Full Product Name

Keap1-Nrf2-IN-1

Product Gene Name

Keap1-Nrf2-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

484.52

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C24H24N2O7S

SMILES

OC([C@H]1N(C2=CC=C(N(CC(O)=O)S(C3=CC=C(OC)C=C3)(=O)=O)C4=C2C=CC=C4)CCC1)=O

CAS Number

2232112-72-8

Target & IC50

Keap1 protein: ic50 43nM

Product Categories/Family for Keap1-Nrf2-IN-1, inhibitor

Angiogenesis; Src; Others

Product References and Citations for Keap1-Nrf2-IN-1, inhibitor

Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

Other Notes

Small volumes of Keap1-Nrf2-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Keap1-Nrf2-IN-1 purchase

MBS5753365 is an inhibitor targeting Keap1-Nrf2-IN-1.