KIRA8 Inhibitor

Name: KIRA8 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753371
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753371

Kira8 is a mono-selective IRE1alpha inhibitor that allosterically attenuates IRE1alpha RNase activity (IC50: 5.9nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Kira8, Inhibitor

Full Product Name

Kira8

Product Gene Name

Kira8, inhibitor

Product Synonym Names

AMG-18

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

601.12

Solubility

DMSO: 65mg/mL (108.13mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C31H29ClN6O3S

SMILES

O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O

CAS Number

1630086-20-2

Target & IC50

IRE1alpha: ic50 5.9nM
IRE1alpha RNase

In Vitro

One week treatment of pre-diabetic NODs mice with Kira8 (50mg/kg; i.p.; once a day) causes obvious reductions in islet XBP1 splicing and TXNIP mRNAs. It also preserves Ins1/Ins2, BiP, and MANF mRNAs. Male Ins2+/Akita mice are injected i.p. with KIRA8 (50mg/kg; daily; for 35 days), obviously reduction of hyperglycemia becomes apparent over several weeks [1].

Product Categories/Family for Kira8, inhibitor

Metabolism; Others

Product References and Citations for Kira8, inhibitor

Morita S, et al. Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25(4):883-897.e8.
Morita S, et al. Targeting ABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25(4):883-897.e8.

Other Notes

Small volumes of Kira8, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Kira8 purchase

MBS5753371 is an inhibitor targeting Kira8.