LDH-IN-1 Inhibitor

Name: LDH-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753398
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753398

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27nM for LDHA and LDHB, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LDH-IN-1, Inhibitor

Full Product Name

LDH-IN-1

Product Gene Name

LDH-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

99.84%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

570.68

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H26N4O4S2

SMILES

O=S(C1=CC=C(CC2=C(N(C3=NC(C(O)=O)=CS3)N=C2C4=CC=CC(C5=CC=CC=C5)=C4)CC6CC6)C=C1)(N)=O

CAS Number

1964515-43-2

Target & IC50

LDHA: ic50 32nM
LDHB: ic50 27nM

In Vitro

LDH-IN-1 exhibit lownM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.

Product Categories/Family for LDH-IN-1, inhibitor

Metabolism; Dehydrogenase

Product References and Citations for LDH-IN-1, inhibitor

Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204.
Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204.

Other Notes

Small volumes of LDH-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LDH-IN-1 purchase

MBS5753398 is an inhibitor targeting LDH-IN-1.