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LEQ506 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753405

LEQ506 is a second-generation smoothened (Smo) inhibitor with IC50s of 4 and 2nM in mouse and human, respectively. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LEQ506, Inhibitor
Full Product Name
LEQ506
Product Gene Name
LEQ506, inhibitor
Product Synonym Names
NVP-LEQ506
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
432.56
Solubility
DMSO: 100mg/mL (231.18mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C25H32N6O
SMILES
OC(C)(C)C1=NC=C(N2[C@H](C)CN(C3=NN=C(CC4=CC=CC=C4)C(C)=C3C)CC2)N=C1
CAS Number
1204975-42-7
Target & IC50
human smo: ic50 2nM
mouse smo: ic50 4nM
In Vitro
LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1[2].LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[1].

Structure of LEQ506, inhibitor

LEQ506 Inhibitor – Cat# MBS5753405

Product References and Citations for LEQ506, inhibitor

Peukert S, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.
Peukert S, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.
Lauressergues E, et al. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e0021
Lauressergues E, et al. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.

Other Notes

Small volumes of LEQ506, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LEQ506 purchase

MBS5753405 is an inhibitor targeting LEQ506.
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