Litronesib Inhibitor

Name: Litronesib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753419
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753419

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Litronesib, Inhibitor

Full Product Name

Litronesib

Product Synonym Names

LY-2523355; KF-89617

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

511.7

Solubility

DMSO: 50mg/mL (97.71mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H37N5O4S2

SMILES

CC(C)(C)C(N1[C@@](C2=CC=CC=C2)(CNS(CCNCC)(=O)=O)SC(NC(C(C)(C)C)=O)=N1)=O

CAS Number

910634-41-2

Target & IC50

Eg5

In Vitro

Litronesib (LY2523355; 1.1, 3.3, 10, and 30mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].

Product Categories/Family for Litronesib, inhibitor

Cytoskeletal Signaling; Kinesin

Product References and Citations for Litronesib, inhibitor

Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14(11):2463-72.
Ye XS, et al. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol Cancer Ther. 2015 Nov;14(11):2463-72.

Other Notes

Small volumes of Litronesib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Litronesib purchase

MBS5753419 is an inhibitor targeting Litronesib.