LRRK21 Inhibitor – LRRK2 1

Name: LRRK21 Inhibitor; LRRK2 1; MyBioSource
Brand: MyBioSource
SKU: MBS5753426
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753426

LRRK2 inhibitor 1 is a selective, potent and oral LRRK2 inhibitor with an pIC50 of 6.8nM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LRRK2 1 (LRRK21), Inhibitor

Full Product Name

LRRK2 inhibitor 1

Product Gene Name

LRRK21, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

397.43

Solubility

DMSO: 62.5mg/mL (157.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H23N5O4

SMILES

CCOC1=NC(NC2=C(OC)C=C(C(N3CCOCC3)=O)C=C2)=NC4=C1C=CN4

CAS Number

1802525-61-6

Target & IC50

LRRK2: ic50 6.8nM (pIC50)

Product Categories/Family for LRRK21, inhibitor

Autophagy; LRRK2

Product References and Citations for LRRK21, inhibitor

Ding X, et al. Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28(9):1615-1620.
Ding X, et al. Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28(9):1615-1620.

Other Notes

Small volumes of LRRK21, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRK21 purchase

MBS5753426 is an inhibitor targeting LRRK21. Also known as LRRK2 inhibitor 1.