MCL-1/BCL-2-IN-1 Inhibitor

Name: MCL-1/BCL-2-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753464
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753464

MCL-1/BCL-2-IN-2 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 uM, respectively. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCL-1/BCL-2-IN-1, Inhibitor

Full Product Name

MCL-1/BCL-2-IN-1

Product Gene Name

MCL-1/BCL-2-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

587.53

Solubility

DMSO: 10mg/mL (17.02mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C31H27BrN2O3S

SMILES

O=C(N(CCNC(C1=CC=C(C(C)(C)C)C=C1)=O)C2=O)C3=CC=C(SC4=CC=C(Br)C=C4)C5=C3C2=CC=C5

Target & IC50

Mcl-1: ic50 4.45uM
Bcl-2: ic50 3.18uM

Product Categories/Family for MCL-1/BCL-2-IN-1, inhibitor

Apoptosis; BCL

Product References and Citations for MCL-1/BCL-2-IN-1, inhibitor

Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Other Notes

Small volumes of MCL-1/BCL-2-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MCL-1/BCL-2-IN-1 purchase

MBS5753464 is an inhibitor targeting MCL-1/BCL-2-IN-1.