MI-1061 Inhibitor

Name: MI-1061 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753481
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753481

MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MI-1061, Inhibitor

Full Product Name

MI-1061

Product Gene Name

MI-1061, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

582.45

Solubility

DMSO: 300mg/mL (515.07mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C30H26Cl2FN3O4

SMILES

O=C(O)C1=CC=C(NC([C@H](N2)[C@H](C3=CC=CC(Cl)=C3F)[C@]4(C(NC5=C4C=CC(Cl)=C5)=O)C62CCCCC6)=O)C=C1

CAS Number

1410737-34-6

Target & IC50

MDM2: ic50 0.16nM (ki)

In Vitro

MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1].

Product Categories/Family for MI-1061, inhibitor

Apoptosis; Mdm2

Product References and Citations for MI-1061, inhibitor

Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.
Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.

Other Notes

Small volumes of MI-1061, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MI-1061 purchase

MBS5753481 is an inhibitor targeting MI-1061.