• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Niraparib R-enantiomer Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753495

MBS5753495 is an inhibitor targeting Niraparib R-enantiomer. Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4nM). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Niraparib R-enantiomer, Inhibitor
Full Product Name
Niraparib R-enantiomer
Product Synonym Names
MK 4827 (R-enantiomer)
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
320.39
Solubility
DMSO: 32mg/mL (99.88mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C19H20N4O
SMILES
O=C(C1=CC=CC2=CN(C3=CC=C([C@@H]4CNCCC4)C=C3)N=C12)N
CAS Number
1038915-58-0
Target & IC50
PARP-1: ic50 2.4nM
In Vitro
Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30nM, Niraparib S-enantiomer=4.0nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34nM). [1].

Structure of Niraparib R-enantiomer, inhibitor

Niraparib R-enantiomer Inhibitor – Cat# MBS5753495

Product References and Citations for Niraparib R-enantiomer, inhibitor

Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.
Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

Other Notes

Small volumes of Niraparib R-enantiomer, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000