MM-589 Inhibitor – TFA

Name: MM-589 Inhibitor; TFA; MyBioSource
Brand: MyBioSource
SKU: MBS5753511
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753511

MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MM-589 TFA, Inhibitor

Full Product Name

MM-589 TFA

Product Gene Name

MM-589, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

686.72

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C30H45F3N8O7

SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2.FC(C(O)=O)(F)F

CAS Number

2097887-21-1

Target & IC50

WDR5: ic50 0.90nM
HMT: ic50 12.7nM

In Vitro

MM-589 inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].

Product Categories/Family for MM-589, inhibitor

Angiogenesis; JAK; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells

Product References and Citations for MM-589, inhibitor

Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.
Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.

Other Notes

Small volumes of MM-589, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MM-589 purchase

MBS5753511 is an inhibitor targeting MM-589. Also known as MM-589 TFA.