Morphothiadin Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

509.39

DMSO: 100mg/mL (196.31mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

C21H22BrFN4O3S

O=C(C1=C(CN2CCOCC2)NC(C3=NC=CS3)=NC1C4=CC=C(F)C=C4Br)OCC

1092970-12-1

HBV: ic50 12nM

Virus titers have increased 83.5-fold in mice treated with 3.75mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5mg/kg per day significantly suppresses the virus replication cycle throughout the treatment,period, while Morphothiadin doses of >15mg/kg per day suppresses virus for up to 2 weeks after the end of treatment,2].

Microbiology&virology; HBV