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MS31 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753522

MBS5753522 is an inhibitor targeting MS31. MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MS31, Inhibitor
Full Product Name
MS31
Product Gene Name
MS31, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
341.45
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C20H27N3O2
SMILES
NCC1=CC(CN)=C(OC)C(OCCCN2CC(C=CC=C3)=C3C2)=C1
CAS Number
2366264-12-0
Target & IC50
SPIN1 by AlphaLISA: ic50 77nM
SPIN1 by FP: ic50 243nM
SPIN1: ic50 91nM (kd)
In Vitro
MS31(compound 3) is a potent, selective, and cell-active SPIN1 inhibitor, Compound 3 potently inhibited binding of trimethyllysine-containing peptides to SPIN1, displayed high binding affinity, was highly selective for SPIN1 over other epigenetic readers and writers, directly engaged SPIN1 in cells, and was not toxic to nontumorigenic cells[1].

Structure of MS31, inhibitor

MS31 Inhibitor – Cat# MBS5753522

Product References and Citations for MS31, inhibitor

Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.
Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J Med Chem. 2019 Jul 24.

Other Notes

Small volumes of MS31, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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