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MS402 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753524

MBS5753524 is an inhibitor targeting MS402. MS402 is a novel BD1-selective BET BrD inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MS402, Inhibitor
Full Product Name
MS402
Product Gene Name
MS402, inhibitor
Form/Format
Solid. Powder
Purity/Purification
100.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
370.83
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C20H19ClN2O3
SMILES
COc1ccc(NC(=O)c2ccc(NC3=C(C)C(=O)CC3)c(Cl)c2)cc1
CAS Number
1672684-68-2
Target & IC50
BRD4-BD1: ic50 77nM (ki)
BRD2-BD1: ic50 83nM (ki)
BRD3-BD1: ic50 110nM (ki)
BRD3-BD2: ic50 200nM (ki)
BRD2-BD2: ic50 240nM (ki)
BRD4-BD2: ic50 718nM (ki)

Product Categories/Family for MS402, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Structure of MS402, inhibitor

MS402 Inhibitor – Cat# MBS5753524

Product References and Citations for MS402, inhibitor

Cheung K, et al. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.
Cheung K, et al. BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.

Other Notes

Small volumes of MS402, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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