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MYCi361 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753535

MBS5753535 is an inhibitor targeting MYCi361. MYCi361 is an inhibitor of MYC (binding to MYC with Kd of 3.2uM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYCi361, Inhibitor
Full Product Name
MYCi361
Product Gene Name
MYCi361, inhibitor
Product Synonym Names
NUCC-0196361
Form/Format
Solid. Powder
Purity/Purification
99.13%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
594.86
Solubility
DMSO: 100mg/mL (168.1mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H16ClF9N2O2
SMILES
Cn1nc(cc1-c1ccc(OCc2ccc(Cl)cc2)c(-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1O)C(F)(F)F
CAS Number
2289690-31-7
Target & IC50
Others
MYC: ic50 3.2uM (Kd)
In Vitro
MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.

Product Categories/Family for MYCi361, inhibitor

Cell Cycle/Checkpoint

Structure of MYCi361, inhibitor

MYCi361 Inhibitor – Cat# MBS5753535

Product References and Citations for MYCi361, inhibitor

Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.

Other Notes

Small volumes of MYCi361, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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