NMS-P715 Inhibitor

MBS5753583 is an inhibitor targeting NMS-P715. NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182nM).

Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy withnMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.
Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy withnMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.
Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitornMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.
Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitornMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.

Small volumes of NMS-P715, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.