ORM-10962 Inhibitor

ORM-10962 is a potent, highly selective inhibitor of sodium-calcium exchanger (NCX) (for the reverse and forward mode inhibition with IC50 values of 67 and 55nM, respectively).

Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias In vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.
Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias In vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.
Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.
Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.

Small volumes of ORM-10962, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5753624 is an inhibitor targeting ORM-10962.