Paprotrain Inhibitor

Paprotrain is a cell-permeable the kinesin MKLP-2 inhibitor(inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35uM and a Ki of 3.36uM)

Labria¨re C, et al. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:920-934.
Labria¨re C, et al. Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem. 2016 Nov 29;124:920-934.
Liu J, et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol. 2013 Dec 21;11:117.
Liu J, et al. MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation. Reprod Biol Endocrinol. 2013 Dec 21;11:117.
Zhang Y, et al. KIF20A regulates porcine oocyte maturation and early embryo development.
Zhang Y, et al. KIF20A regulates porcine oocyte maturation and early embryo development.
Tcherniuk S, et al. Relocation of AuroraB and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31.
Tcherniuk S, et al. Relocation of AuroraB and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31.

Small volumes of Paprotrain, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5753640 is an inhibitor targeting Paprotrain.