PAT-505 Inhibitor

Name: PAT-505 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753647
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753647

PAT-505 is a selective, noncompetitive and orally available inhibitor of autotaxin(IC50 of 2nM in Hep3B cells, 9.7nM in human blood and 62nM in mouse plasma). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PAT-505, Inhibitor

Full Product Name

PAT-505

Product Gene Name

PAT-505, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

473.92

Solubility

DMSO: 48.33mg/mL (101.98mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H18ClF2N3O2S

SMILES

O=C(O)C1=CC=CC(SC2=C(C3CC3)N(C4=CN(CC)N=C4)C5=C2C=CC(Cl)=C5F)=C1F

CAS Number

1782070-22-7

Target & IC50

Autotaxin: ic50 62nM (in mouse plasma)

Product Categories/Family for PAT-505, inhibitor

Metabolism; PDE

Product References and Citations for PAT-505, inhibitor

Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.
Bain G, et al. Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13. Epub 2016 Oct 17.

Other Notes

Small volumes of PAT-505, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAT-505 purchase

MBS5753647 is an inhibitor targeting PAT-505.