PF-06726304 Inhibitor

Name: PF-06726304 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753675
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753675

PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0nM, respectively). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PF-06726304, Inhibitor

Full Product Name

PF-06726304

Product Gene Name

PF-06726304, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

446.33

Solubility

DMSO: 15mg/mL (33.61mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H21Cl2N3O3

SMILES

O=C1N(CC2=C(C)C=C(C)NC2=O)CCC3=C1C(Cl)=C(C4=C(C)ON=C4C)C=C3Cl

CAS Number

1616287-82-1

Target & IC50

EZH2 WT: ic50 0.7nM (ki)
EZH2 Y641N: ic50 3.0nM (ki)

In Vitro

In a subcutaneous Karpas-422 xenograft model, PF-06726304 (200 and 300mg/kg; BID for 20 days) suppresses tumor growth and causes robust modulation of downstream biomarkers[1].

Product Categories/Family for PF-06726304, inhibitor

Chromatin/Epigenetic; Histone Methyltransferase

Product References and Citations for PF-06726304, inhibitor

Kung PP, et al. Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors. J Med Chem. 2016 Sep 22;59(18):8306-25.
Kung PP, et al. Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors. J Med Chem. 2016 Sep 22;59(18):8306-25.

Other Notes

Small volumes of PF-06726304, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06726304 purchase

MBS5753675 is an inhibitor targeting PF-06726304.