PI3K/mTOR-2 Inhibitor

Name: PI3K/mTOR-2 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753690
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753690

PI3K/mTOR Inhibitor-2 is a potent dual inhibitor of pan-PI3K/mTOR(PI3Kalpha/PI3Kbeta/PI3Kdelta/PI3Kgamma/mTOR with IC50s of 3.4/34/16/1/4.7nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PI3K/mTOR-2, Inhibitor

Full Product Name

PI3K/mTOR Inhibitor-2

Product Gene Name

PI3K/mTOR-2, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

478.86

Solubility

DMSO: 8.33mg/mL (17.40mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H13ClF2N4O4S

SMILES

FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1

CAS Number

1848242-58-9

Target & IC50

PI3Kalpha: ic50 3.4nM
PI3Kbeta: ic50 34nM
PI3Kdelta: ic50 16nM
PI3Kgamma: ic50 1nM
mTOR: ic50 4.7nM

In Vitro

PI3K/mTOR Inhibitor-2(Compound 31) exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays, and good pharmacokinetic profile.

Product Categories/Family for PI3K/mTOR-2, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for PI3K/mTOR-2, inhibitor

Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.
Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.

Other Notes

Small volumes of PI3K/mTOR-2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PI3K/mTOR-2 purchase

MBS5753690 is an inhibitor targeting PI3K/mTOR-2. Also known as PI3K/mTOR Inhibitor-2.