PI4KIIIbeta3 Inhibitor – Cat# MBS5753691

PI4KIIIbeta3 Inhibitor – PI4KIII Beta 3

Name: PI4KIIIbeta3 Inhibitor; PI4KIII Beta 3; MyBioSource
Brand: MyBioSource
SKU: MBS5753691
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753691

PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIbeta (IC50 of 5.7nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PI4KIII beta 3 (PI4KIIIbeta3), Inhibitor

Full Product Name

PI4KIII beta inhibitor 3

Product Gene Name

PI4KIIIbeta3, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

446.53

Solubility

DMSO: 20mg/mL (44.79mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H22N8OS

SMILES

O=C(N1CCN(C2=C3C(SC(C4=CC=CN=C4)=N3)=NC(N)=N2)CC1)NC5=CC=C(C)C=C5

CAS Number

1245319-54-3

Target & IC50

PI4KIIIbeta: ic50 5.7nM

In Vitro

Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment,(up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party.

Product Categories/Family for PI4KIIIbeta3, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Product References and Citations for PI4KIIIbeta3, inhibitor

Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1
Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1

Other Notes

Small volumes of PI4KIIIbeta3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PI4KIIIbeta3 purchase

MBS5753691 is an inhibitor targeting PI4KIIIbeta3. Also known as PI4KIII beta inhibitor 3.