INCB053914 Inhibitor – Phosphate

Name: INCB053914 Inhibitor; Phosphate; MyBioSource
Brand: MyBioSource
SKU: MBS5753695
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753695

INCB053914 phosphate is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24nM, 30nM, 0.12nM, respectively). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

INCB053914 phosphate, Inhibitor

Full Product Name

INCB053914 phosphate

Product Gene Name

INCB053914, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

611.51

Solubility

DMSO: 5mg/mL (8.18mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H29F3N5O7P

SMILES

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=CN=C4C(CC[C@H]4O)=C3N5C[C@@H](N)[C@H](O)[C@@H](C)C5.OP(O)(O)=O

CAS Number

2088852-47-3

Target & IC50

PIM1: ic50 0.24nM
PIM2: ic50 30nM
PIM3: ic50 0.12nM

Product Categories/Family for INCB053914, inhibitor

Chromatin/Epigenetic; Pim; JAK/STAT signaling

Product References and Citations for INCB053914, inhibitor

Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108.
Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108.

Other Notes

Small volumes of INCB053914, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INCB053914 purchase

MBS5753695 is an inhibitor targeting INCB053914. Also known as INCB053914 phosphate.