PKC-IN-1 Inhibitor

Name: PKC-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753704
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753704

PKC-IN-1 is a ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCalpha, PKCbetaI, PKCbetaII, PKCtheta, PKCgamma, PKC mu and PKCepsilon with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PKC-IN-1, Inhibitor

Full Product Name

PKC-IN-1

Product Gene Name

PKC-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

500.61

Solubility

DMSO: 25mg/mL (49.94mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C25H37FN8O2

SMILES

O=C(N1[C@@H](C)CN(CC2CCOCC2)[C@H](C)C1)N(C3)C(C)(C)C4=C3C(NC5=NC(C)=NC=C5F)=NN4

CAS Number

1046787-18-1

Target & IC50

Human PKCalpha: ic50 10.4nM (ki)
Human PKCbetaII: ic50 7.6nM
Human PKCbetaI: ic50 8.1nM
Human PKCtheta: ic50 25.6nM
Human PKCgamma: ic50 57.5nM
Human PKC mu: ic50 314nM
Human PKCepsilon: ic50 808nM
Human PKCbeta: ic50 5.3nM (ki)

In Vitro

in Lewis rats, PKC-IN-1 dose-dependently and significantly reduces maximum EAE severity and end severity in autoimmune encephalitis (EAE) model [1].

Product Categories/Family for PKC-IN-1, inhibitor

Cytoskeletal Signaling; PKC

Product References and Citations for PKC-IN-1, inhibitor

Michael Niesman, et al. treatment,of autoimmune disease. WO2015179847A1.
Michael Niesman, et al. treatment,of autoimmune disease. WO2015179847A1.

Other Notes

Small volumes of PKC-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PKC-IN-1 purchase

MBS5753704 is an inhibitor targeting PKC-IN-1.