B-Ra Inhibitor – B-Raf Degrader 1

Name: B-Ra Inhibitor; B-Raf Degrader 1; MyBioSource
Brand: MyBioSource
SKU: MBS5753728
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753728

PROTAC B-Raf degrader 1 is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf,PROTAC B-Raf degrader 1 With anti-cancer activity. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

B-Raf degrader 1, Inhibitor

Full Product Name

PROTAC B-Raf degrader 1

Product Gene Name

B-Ra, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

763.77

Solubility

DMSO: 25mg/mL (32.73mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C36H37N5O12S

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CNC(CNC4=CC(CS(=O)(/C=C/C5=C(OC)C=C(OC)C=C5OC)=O)=CC=C4OC)=O

CAS Number

2364367-27-9

Target & IC50

B-Raf

Product Categories/Family for B-Ra, inhibitor

MAPK; Raf

Product References and Citations for B-Ra, inhibitor

Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Mar 19;87:191-199.
Chen H, et al. Pomalidomide hybrids act as proteolysis targeting chimeras: Synthesis, anticancer activity and B-Raf degradation. Bioorg Chem. 2019 Mar 19;87:191-199.

Other Notes

Small volumes of B-Ra, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for B-Ra purchase

MBS5753728 is an inhibitor targeting B-Ra. Also known as PROTAC B-Raf degrader 1.