(-)-PX20606 Inhibitor – (-)-PX20606 Trans Isomer

Name: (-)-PX20606 Inhibitor; (-)-PX20606 Trans Isomer; MyBioSource
Brand: MyBioSource
SKU: MBS5753748
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753748

(-)-PX20606 trans isomer is an agonist of FXR (EC50s: 18 and 29nM for FXR in FRET and M1H assay, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

(-)-PX20606 trans isomer, Inhibitor

Full Product Name

(-)-PX20606 trans isomer

Product Gene Name

(-)-PX20606, inhibitor

Product Synonym Names

(-)-PX-102 trans isomer; (-)-PX-104

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

554.85

Solubility

Ethanol: 50mg/mL (90.11mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C29H22Cl3NO4

SMILES

ClC1=C(C2=NOC(C3CC3)=C2COC4=CC=C([C@@H]5C[C@H]5C6=CC=C(C(O)=O)C=C6)C(Cl)=C4)C(Cl)=CC=C1.[(-)].[Rotation]

CAS Number

1268244-88-7

Target & IC50

FXR in FRET assay: ic50 18nM (EC50)
FXR in M1H assay: ic50 29nM (EC50)

Product Categories/Family for (-)-PX20606, inhibitor

Metabolism; FXR

Product References and Citations for (-)-PX20606, inhibitor

1. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53.

Other Notes

Small volumes of (-)-PX20606, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (-)-PX20606 purchase

MBS5753748 is an inhibitor targeting (-)-PX20606. Also known as (-)-PX20606 trans isomer.