(R)-BMS-816336 Inhibitor

Name: (R)-BMS-816336 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753765
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753765

(R)-BMS-816336 is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme(IC50s of 14.5nM, 50.3nM and 16nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

(R)-BMS-816336, Inhibitor

Full Product Name

(R)-BMS-816336

Product Gene Name

(R)-BMS-816336, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

341.44

Solubility

DMSO: 300mg/mL (878.63mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H27NO3

SMILES

O[C@H]1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](C[C@H]1C3)C2

CAS Number

1009583-83-8

Target & IC50

Human 11beta-HSD1: ic50 14.5nM
Mouse 11beta-HSD1: ic50 50.3nM
Cynomolgus monkey 11beta-HSD1: ic50 16nM

Product Categories/Family for (R)-BMS-816336, inhibitor

Metabolism; Dehydrogenase

Product References and Citations for (R)-BMS-816336, inhibitor

Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.
Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.

Other Notes

Small volumes of (R)-BMS-816336, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (R)-BMS-816336 purchase

MBS5753765 is an inhibitor targeting (R)-BMS-816336.