FT671 Inhibitor

Name: FT671 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753773
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753773

FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52nM) It also binds to the USP7 catalytic domain (Kd: 65nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FT671, Inhibitor

Full Product Name

FT671

Product Gene Name

FT671, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

533.48

Solubility

DMSO: 50mg/mL (93.72mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H23F4N7O3

SMILES

FC1=CC=C(N2N=CC3=C2N=CN(CC4(O)CCN(C(C[C@@H](C(F)F)N5N=C(F)C=C5)=O)CC4)C3=O)C=C1

CAS Number

1959551-26-8

Target & IC50

USP7: ic50 52nM

In Vitro

FT671 is well-to related even at high doses. FT671 (100mg/kg and 200mg/kg, oral gavage, daily) treatment,in mice causes an obviously dose-dependent inhibition of tumor growthours.

Product Categories/Family for FT671, inhibitor

Ubiquitination; DUB

Product References and Citations for FT671, inhibitor

Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486.
Turnbull AP, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017 Oct 26;550(7677):481-486.

Other Notes

Small volumes of FT671, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FT671 purchase

MBS5753773 is an inhibitor targeting FT671.