Reparixin L-lysine salt Inhibitor

Name: Reparixin L-lysine salt Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753810
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753810

Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Reparixin L-lysine salt, Inhibitor

Full Product Name

Reparixin L-lysine salt

Product Synonym Names

Repertaxin L-lysine salt

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

429.57

Solubility

H2O: 100mg/mL (232.79mM) Need ultrasonic
DMSO: 100mg/mL (232.79mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H35N3O5S

SMILES

N[C@@H](CCCCN)C(O)=O.CS(=O)(NC([C@@H](C1=CC=C(CC(C)C)C=C1)C)=O)=O

CAS Number

266359-93-7

Target & IC50

CXCR1wt: ic50 5.6nM (in L1.2 cells)
CXCR1Ile43Val: ic50 80nM (in L1.2 cells)
CXCR1: ic50 1nM (in cells)
CXCR2: ic50 100nM (in cells)

In Vitro

Reparixin is a potent CXCL8-induced inhibitor biological activities on human PMNs, with a marked selectivity (around 400-fold) for CXCR1, as shown in specific experiments on CXCR1/L1.2 and CXCR2/L1.2 transfected cells and on human PMNs.Reparixin is a non-competitive allosteric inhibitor of IL-8 receptors with a 400-fold higher efficacy in inhibiting CXCR1 activity than CXCR2[2]. The efficacy of Reparixin is significantly lower in L1.2 cells expressing Ile43Val CXCR1 mutant (IC50 values of 5.6nM and 80nM for CXCR1 wt and CXCR1 Ile43Val, respectively)[1].

Product Categories/Family for Reparixin L-lysine salt, inhibitor

Autophagy; CXCR; GPCR/G Protein; Immunology/Inflammation

Product References and Citations for Reparixin L-lysine salt, inhibitor

Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002.
Moriconi A, et al. Design of noncompetitive interleukin-8 inhibitors acting on CXCR1 and CXCR2. J Med Chem. 2007 Aug 23;50(17):3984-4002.
Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54.
Bertini R, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/CXCR2non-competitive allosteric inhibitor. Br J Pharmacol. 2012 Jan;165(2):436-54.
Midgley I, et al. Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog. Xenobiotica. 2006 May;36(5):419-40
Midgley I, et al. Species differences in the pharmacokinetics and metabolism of reparixin in rat and dog. Xenobiotica. 2006 May;36(5):419-40
Catrina, Anca, et al. METHODS AND COMPOUNDS FOR THE treatment,OF BONE LOSS AND/OR PAIN. US 20170105971 A1.
Catrina, Anca, et al. METHODS AND COMPOUNDS FOR THE treatment,OF BONE LOSS AND/OR PAIN. US 20170105971 A1.
Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6.
Bertini R, et al. Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6.

Other Notes

Small volumes of Reparixin L-lysine salt, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Reparixin L-lysine salt purchase

MBS5753810 is an inhibitor targeting Reparixin L-lysine salt.