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RG7834 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753818

RG7834 is a highly selective and orally bioavailable inhibitor of HBV(HBsAg and HBeAg and HBV DNA with IC50s of 2.8, 2.6, and 3.2nM, respectively, in dHepaRG Cells). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RG7834, Inhibitor
Full Product Name
RG7834
Product Gene Name
RG7834, inhibitor
Product Synonym Names
RO 7020322
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
401.45
Solubility
DMSO: 125mg/mL (311.37mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C22H27NO6
SMILES
O=C(O)C1=CN2[C@@H](CC3=CC(OCCCOC)=C(C=C3C2=CC1=O)OC)C(C)C
CAS Number
2072057-17-9
Target & IC50
HBsAg: ic50 2.8nM
HBeAg: ic50 2.6nM
HBV DNA: ic50 3.2nM
In Vitro
In HBV-infected human liver chimeric uPA-SCID mice,RG7834 shows anti-HBV efficacy. RG7834 (2, 14.5mg/kg, p.o.) exhibits good oral bioavail ability, and with a half-life of 4.9 h in mice.

Structure of RG7834, inhibitor

RG7834 Inhibitor – Cat# MBS5753818

Product References and Citations for RG7834, inhibitor

Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.
Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.

Other Notes

Small volumes of RG7834, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RG7834 purchase

MBS5753818 is an inhibitor targeting RG7834.
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