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Ribocil-C Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753821

MBS5753821 is an inhibitor targeting Ribocil-C. Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Ribocil-C, Inhibitor
Full Product Name
Ribocil-C
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
419.5
Solubility
DMSO: 24.6mg/mL (58.64mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H21N7OS
SMILES
O=C1C=C(C2=CC=CS2)NC([C@H]3CCCN(CC4=CN(C5=NC=CC=N5)C=N4)C3)=N1
CAS Number
1825355-56-3
Target & IC50
Bacterial riboflavin riboswitches
In Vitro
Ribocil-C treatment, groups (60 and 120 mg kg21 ribocil-C) show a dose-dependent reduction in the bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice. There is no mortality or gross effects of toxicity observed [2].

Product Categories/Family for Ribocil-C, inhibitor

Microbiology&virology; Antibacterial

Structure of Ribocil-C, inhibitor

Ribocil-C Inhibitor – Cat# MBS5753821

Product References and Citations for Ribocil-C, inhibitor

Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588.
Wang H, et al. Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch DisruptRiboflavin Homeostasis in an Infectious Setting. Cell Chem Biol. 2017 May 18;24(5):576-588.
Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.
Howe JA, et al. Selective small-molecule inhibition of an RNA structural element. Nature. 2015 Oct 29;526(7575):672-7.

Other Notes

Small volumes of Ribocil-C, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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