Rislenemdaz Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

358.41

DMSO: 100mg/mL (279.01mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

C19H23FN4O2

O=C(N1C[C@@H](F)[C@@H](CNC2=NC=CC=N2)CC1)OCC3=CC=C(C)C=C3

808732-98-1

GluN2B: ic50 8.1nM (ki)

Rislenemdaz plasma levels are approximately 15, 120, 390, 1420, 4700, and 14,110nM (0.015, 0.120, 0.390, 1.42, 4.7, and 14.11uM) at the time of sampling, corresponding to approximately 5, 29, 56, 83, 94, and 98% RO, respectively, in rats. The ED50 for increaing in frequency of swimming and decreasing in immobility are ~0.3 and 0.7mg/kg, respectively, corresponding to RO of ~30 and 50%. Rislenemdaz (1, 3, 10, and 30mg/kg) significantly increases total distance traveling (P<0.01 for 1mg/kg; P<0.001 for 3, 10, and 30mg/kg) compare to vehicle control over the 60 min test.