Guadecitabine sodium Inhibitor

Name: Guadecitabine sodium Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753847
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753847

Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Guadecitabine sodium, Inhibitor

Full Product Name

Guadecitabine sodium

Product Synonym Names

SGI-110 sodium; S-110 sodium

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

579.39

Solubility

DMSO: 50mg/mL (86.30mM) Need ultrasonic
H2O: Soluble
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H23N9NaO10P

SMILES

O=C1C2=C(N([C@H]3C[C@H](O)[C@@H](COP(O[C@@H]4[C@@H](CO)O[C@@H](N5C=NC(N)=NC5=O)C4)([O-])=O)O3)C=N2)NC(N)=N1.[Na+]

CAS Number

929904-85-8

Target & IC50

DNMT1

In Vitro

Guadecitabine sodium(10mg/kg)is an effective dose at reducing DNA methylation and retarding tumor growth, and caused roughly the same level of toxicity as 5-Aza-CdR. Guadecitabine sodium is effective in vivo at reactivating the expression of the p16 gene, which is heavily methylated in the parent EJ6 cells. Guadecitabine sodium is effective in reducing the level of DNA methylation in vivo at the p16 promoter region. Guadecitabine sodium is better tolerated than 5-Aza-CdR in vivo[2].

Product Categories/Family for Guadecitabine sodium, inhibitor

Chromatin/Epigenetic; DNA Methyltransferase

Product References and Citations for Guadecitabine sodium, inhibitor

Yoo CB, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8.
Yoo CB, et al. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8.
Chuang JC, et al. S-110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50.
Chuang JC, et al. S-110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth. Mol Cancer Ther. 2010 May;9(5):1443-50.

Other Notes

Small volumes of Guadecitabine sodium, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Guadecitabine sodium purchase

MBS5753847 is an inhibitor targeting Guadecitabine sodium.