S130 Inhibitor

Name: S130 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5753861
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5753861

S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24uM).It suppresses autophagy flux. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

S130, Inhibitor

Full Product Name

S130

Product Gene Name

S130, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

387.47

Solubility

DMSO: 125mg/mL (322.61mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H25N3O2

SMILES

O=C1C2=CC=CC=C2C3=C4C1=NC=C(C(NCCCN(CC)CC)=O)C4=CC=C3

CAS Number

1160852-22-1

Target & IC50

ATG4B: ic50 3.24uM

In Vitro

Tumor growth suppressed by S130 (20mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs.

Product Categories/Family for S130, inhibitor

Proteases/Proteasome; Cysteine Protease

Product References and Citations for S130, inhibitor

Fu Y, et al. Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo. Autophagy. 2018 Sep 20:1-17.

Other Notes

Small volumes of S130, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for S130 purchase

MBS5753861 is an inhibitor targeting S130.